Exploring the Microbiota-Gut-Brain Axis for Mental Disorders with Knowledge Graphs

Research Articie December 15,2020

Ting Liu ¹ , Xueli Pan ² , Xu Wang ³ , Jaap Heringa ⁴ , Zhisheng Huang ⁵ hide author's information

1 : Center for Integrative Bioinformatics VU (IBIVU), Vrije Universiteit, Amsterdam, The Netherlands
2 : Knowledge Representation and Reasoning (KR&R) Group, Vrije Universiteit, Amsterdam, The Netherlands
3 : Knowledge Representation and Reasoning (KR&R) Group, Vrije Universiteit, Amsterdam, The Netherlands
4 : Center for Integrative Bioinformatics VU (IBIVU), Vrije Universiteit, Amsterdam, The Netherlands
5 : Knowledge Representation and Reasoning (KR&R) Group, Vrije Universiteit, Amsterdam, The Netherlands

DOI: https://doi.org/10.2991/jaims.d.201208.001

Keywords: Microbiota-gut-brain axis; Gut microbiota; Neurotransmitter; Mental disorder; Knowledge graph; Biomedical ontology

Cite this article: Liu T, Pan X, Wang X, Feenstra KA, Heringa J, Huang Z. Exploring the Microbiota-Gut-Brain Axis for Mental Disorders with Knowledge Graphs. JAIMS [Internet]. 1(3-4):30-42.

Full Text

PDF

Download Citation

Abstract

Gut microbiota has a significant influence on brain-related diseases through the communication routes of the gut-brain axis. Many species of gut microbiota produce a variety of neurotransmitters. In essence, the neurotransmitters are chemicals that influence mood, cognition, and behavior of the host. The relationships between gut microbiota and neurotransmitters has received much attention in medical and biomedical research. However, the integration of the various proposed neurotransmitter signal routes that underpin these relationships has not yet been studied well....