Journal of Artificial Intelligence for Medical Sciences
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Research Articie October 11,2022
Mutational Analysis and Deep Learning Classification of Uterine and Cervical Cancers
Paul Gomez 1 hide author's information
Keywords: Uterine cancer, Artificial Intelligence (AI), Machine Learning (ML), Deep Learning (DL), TensorFlow
Cite this article: Gomez P. Mutational Analysis and Deep Learning Classification of Uterine and Cervical Cancers. JAIMS. 2022;3(1-2):16-22.
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Abstract


We analyzed tumor mutations of 7 uterine and 2 cervical cancers with the goal of developing a Deep Learning (DL) software tool that can automatically classify tumors based on their somatic mutations. The data were obtained from the AACR Genie Project, that has a collection of more than 120,000 tumor samples for more than 750 cancer types. We performed a thorough analysis of the mutational data of tumors of the uterus and uterine cervix, selecting tumors with 3 or more mutations and cancer types with more than 15 cases. For each cancer type we then selected the top 12 most mutated genes among their neoplasms. In the introduction section we summarize our analysis of these nine diseases and in the methods section we present a convolutional neural network (CNN) that yields an overall classification accuracy of 94.3% and 89.2% on the train and test datasets, respectively. ...